Mechanotransduction in Cardiac Hypertrophy and Failure
نویسندگان
چکیده
منابع مشابه
Mechanotransduction in cardiac hypertrophy and failure.
Cardiac muscle cells have an intrinsic ability to sense and respond to mechanical load through a process known as mechanotransduction. In the heart, this process involves the conversion of mechanical stimuli into biochemical events that induce changes in myocardial structure and function. Mechanotransduction and its downstream effects function initially as adaptive responses that serve as compe...
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The study of ventricular hypertrophy has recently been a fruitful research area. From studies principally in neonatal rat ventricular myocytes in primary culture but now increasingly in transgenic mice, the molecular mechanisms involved in this important pathophysiological adaptation are becoming clearer.1 In culture, cardiomyocyte hypertrophy is characterized by numerous transcriptional and mo...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2015
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.304937